Semax is a synthetic analogue of adrenocorticotropic hormone (ACTH). It consists of the amino acids 4-10 of ACTH.
Semax, which was developed in Russia, has been found to have benefit in the settings of stroke, cognitive impairment, dementia, and inflammation of the optic nerve. It has also been tested as a potential immune system booster and has been found to have antidepressant and anxiolytic properties as well. Research shows that Semax increases levels of brain-derived neurotrophic factor (BDNF) in the central nervous system as well as levels of serotonin and dopamine.